CASP1 and obesity due to melanocortin 4 receptor deficiency: Using mouse diet-induced obesity models, targeting various components of the inflammasome, including NLRP3 [5], [6], caspase-1 [7] and ASC [7] was shown to either prevent obesity, and/or to relieve obesity-induced manifestations [5], in particular whole-body insulin resistance and hepatic steatosis [7], [8].