In addition, some studies have displayed that sFLT-1 binds to and neutralizes the pro-angiogenic actions of VEGF and the contributions of sENG and sFLT-1 to the pathogenesis of maternal preeclampsia are, at least in part, related to their inhibition of TGFβ and VEGF, respectively [41]. This evidence concerns the gene VEGFA and preeclampsia.