In fact, RCMD patients showed high expression levels of pro-angiogenic factors such as VEGF, HIF, and FN1. In contrast, this group of MDS had low ENG expression, high levels of sENG and sFLT-1 in BM microenvironment, a decrease level of VEGF with respect to the expression gene and the reduced vessel formation by endothelial cell lines. Here, ENG is linked to myelodysplastic syndrome.