Immunostaining of ANXA1 was mostly weak or negative in the cytoplasm of cells from tumor margins (control group) (Figure 2A) compared to the samples from the HPV-negative (p<0.01, Tukey’s post hoc test) (Figure 2B and H) and HPV-high-risk (p<0.0001, Tukey’s post hoc test) (Figure 2C and H) groups. The gene discussed is ANXA1; the disease is neoplasm.