Especially, we found a significant clustering (Bonferroni correction P = 8.00E-06) of 8 genes (HLA-DQB1, TNF, HLA-DRB1, HIST1H2AH, HLA-DOB, HLA-DQA2, HLA-DQA1, HLA-DRA) directly involved in SLE. The gene discussed is HLA-DOB; the disease is systemic lupus erythematosus.