In univariate analysis, age (r = 0.227, p<0.001), eGFR (r = −0.274, p<0.001), LVEF (r = −0.35, p<0.001), systolic pulmonary artery pressure (r = 0.283, p<0.001), artery blood pH (r = −0.132, p = 0.020) and LV failure (z = 9.972, p<0.000), atrial fibrillation (z = 4.234, p<0.001), coronary heart disease (z = 2.979, p = 0.003), cor pulmonale (z = 5.417, p<0.001) were significantly correlated with NT-proBNP levels. The gene discussed is NPPB; the disease is atrial fibrillation.