To explore the potential mechanisms of SDR9C7 involved in the metastasis of ESCC, we examined the expression of metastasis-related molecules, including MMP11, VEGF and E-cadherin, in highly invasive cells transfected with SDR9C7 siRNA and control lentivirus (Fig. 5). The gene discussed is CDH1; the disease is esophageal squamous cell carcinoma.