Over-expression of G3BP1 has been detected in a number of human cancers including breast, lung, prostate, colon, thyroid, esophageal, and head and neck cancers [29], and over-expression has also been associated with lymph node metastasis and worse survival in esophageal squamous cell carcinoma [30]. This evidence concerns the gene G3BP1 and metastatic malignant neoplasm in the lymph nodes.