As a result, ly75-morphants developed late-onset heart failure with dilation of the atrium (Fig 8C) and reduced ventricular contractility beginning at the 96 h developmental stage (FS = 46 ± 5% at 48 hpf and 29 ± 4% at 96 hpf; Fig 8E, Supporting Information Movie 1). Here, LY75 is linked to heart failure.