Prior studies have suggested that activated Stat3 promotes tumor growth and metastases, presumably through its critical role in the expression of many genes key to regulation of multiple aspects of tumor cell survival, growth, angiogenesis, and evasion of immune surveillance, such as cyclin D1, MMP-2, VEGF, and 10-kDa IFN-g-induced protein [55]. This evidence concerns the gene STAT3 and neoplasm.