BMI1 and breast carcinoma: Additionally, BMI1 has recently been associated with a stem cell-like 11 gene expression microarray signature predictive of a short interval to disease recurrence following therapy, increased likelihood of metastatic disease, and poor response to therapy in multiple types of human cancer, including prostate, lung, ovarian, urinary bladder, lymphoma, mesothelioma, glioma, acute myeloid leukemia, and breast cancer [79].