To investigate the role of MMP-9 in recurrent/chemoresistant ovarian cancer we carried out functional inhibition of the gene using a chemical inhibitor (2R)-2-[(4-Biphenylsulfonyl) amino]-3 phenylpropionic acid (C21H19NO4S) (MMP-9/MMP-2i). The gene discussed is MMP9; the disease is ovarian carcinoma.