CASR and breast carcinoma: In addition, the CaSR can inhibit breast cancer cell growth through its functional linkage with the tumor-suppressor BRCA1: Promkan et al. [145] reported that BRCA1 up-regulates the expression of the CaSR and, at the same time, functions through the receptor in suppressing the expression of survivin, an anti-apoptotic protein that is present in most cancer cells.