The protein profiles in response to epidermal growth factor (EGF) treatment in ovarian cancer cells were analysed using iTRAQ labelling and mass spectrometry [85].One of the differentially regulated proteins, lysosomal-associated membrane protein-1, in different stages of epithelial ovarian cancers was found to be a promising biomarker in understanding the progression of EGF-stimulated ovarian cancers and to be useful in the prediction of treatment responses involving tyrosine kinase inhibitors or EGF receptor monoclonal antibodies [85]. The gene discussed is EGF; the disease is ovarian carcinoma.