In rats fed a high-fat diet, obesity resulted in activation of PPAR (peroxisome proliferator-activated receptor)-gamma and suppression of Wnt/β-catenin pathways both associated with stimulation of bone marrow adipogenesis and decreased osteoblast differentiation, as a substrate to diminished OC concentration [28]. Here, PPARA is linked to obesity due to melanocortin 4 receptor deficiency.