In recent series of the investigations, Gal-9 is also reported to regulate the virus specific T-cell response [19], T cell immunity in hepatitis C infection [11], anti-microbial immunity [20], it is an important clinical question whether elevated serum levels of Gal-9 in the patients with type 2 diabetes and diabetic nephropathy are related to the susceptibility for various infection in the future studies. This evidence concerns the gene LGALS9 and type 2 diabetes mellitus.