However, on multivariate analysis adjusted for the covariates CRP, RF, anti-CCP2 and arthritis of the hand joints, only arthritis of the hand joints and anti-CCP2, at both low and high titers predicted RA, with a risk of 3.2 for low, and 4.3 for high anti-CCP2 titers at baseline. The gene discussed is AGBL2; the disease is Arthritis.