Nevertheless, a few years later with Nazneen Rahman, my erstwhile PhD student who was now leading the breast cancer genetics group at the Institute of Cancer Research, we started systematically sequencing candidate genes that were part of the DNA damage and repair pathways that include BRCA1/2 and identified a number of intermediate risk (two- to fourfold) breast cancer susceptibility genes including CHEK2, ATM, BRIP1 and PALB2. This evidence concerns the gene CHEK2 and breast cancer.