Evaluation of the relation of cyclin D1 protein expression in the histological sections to cyclin D1 mRNA in the corresponding tumor samples by means of Q-PCR showed that tumors with high cyclin D1 protein had 1.8 times higher expression of cyclin D1 mRNA than those with low or negative cyclin D1 in the histological sections (Figure 4), suggesting that the higher cyclin D1 protein level is at least partially due to increased expression of CCND1. Here, CCND1 is linked to neoplasm.