CDKN2A and breast cancer: In addition, we found a statistically significant correlation between p16 expression and increased breast cancer-specific survival (P = 0.028; HR = 4.0; 95.0% CI = 1.0, 15.0) (Figure 5A) and increased disease-free survival (P = 0.004; HR = 4.1; 95.0% CI = 1.5, 12.0) (Figure 5B), but not with overall survival (data not shown).