In humans, the mutations of Crx are associated with three forms of retinal degeneration, including cone and rod dystrophy (CORD) [11], [12], [13], retinitis pigmentosa (RP) [13], and Leber congenital amaurosis (LCA) [13], [14], all of which can lead to vision loss. The gene discussed is CRX; the disease is Leber congenital amaurosis.