As described above, it is not clear whether specific depletion of Tsc1 in granulosa cells contributes to the fertility/infertility in the Tsc1flox/flox; Amhr2-cre female mice, because of the wide expression of Amhr2-cre in some somatic cells of the reproductive tract [28], [29]. The gene discussed is AMHR2; the disease is Infertility.