MRPS7 and familial pancreatic carcinoma: In this regard, induction of the non-regulatory RRM1 subunit, expression of anti-apoptotic proteins, activation of cell survival genes, and induction of drug-efflux proteins (e.g., MRPs) have been shown to modulate gemcitabine chemosensitization in drug-resistant pancreatic cancer cells [41]–[45].