PPARGC1A may serve as a hub molecule influencing AMD pathogenesis and pathophysiology as it activates the glitazone target PPARG [28], [55], the fenofibrate target PPARA [37], [55], and C3 [24], LIPC [25], and VEGF [33] promoter fragments. Here, PPARGC1A is linked to age-related macular degeneration.