After observing relationships of NV AMD with SNPs in exonic and regulatory regions of PPARGC1A from the meta-analysis, we examined interactions of these variants with established genetic loci for NV AMD resident in systems: 1) associated with AMD in other studies (complement, lipid metabolism, and vascular endothelial growth factor (VEGF) signaling systems); and, 2) responsive to ω-3 LCPUFA feeding in our animal models (complement cascade). This evidence concerns the gene PPARGC1A and age-related macular degeneration.