[26], [27]Via co-activation of PPARG [28], PPARGC1A may alter expression of ABCA1[29], [30], [31] and VEGFA. [32], [33]ABCA1 and VEGFA carry AMD-associated sequence variants. [26], [34], [35], [36]Via co-activation of PPARA [37], [38], [39], [40], PPARGC1A may alter expression of CFH [41], and C2. [42] These genes carry AMD-associated sequence variants. [43], [44] In our cohorts, PPARGC1A SNPs showed statistical interactions with CFB, C3, C2, VEGFA, FLT1, and KDR variants. FLT1 and KDR encode VEGFA receptors. This evidence concerns the gene C3 and age-related macular degeneration.