[56] Troglitazone inhibited choroidal neovascularization in a in vivo primate model of NV AMD. [21] Fenofibrate, a synthetic PPAR activator, reduced the need for laser treatment for proliferative diabetic retinopathy. [22] Chemical structures for PPAR agonists exist at (Kanehisa Laboratories, www.genome.jp/kegg/pathway/map/map07222.html. Accessed 2012 Nov 30); those for RXR agonists and antagonists are presented at (Kanehisa Laboratories, www.genome.jp/kegg/pathway/map/map07223.html. This evidence concerns the gene PPARA and proliferative diabetic retinopathy.