PPARGC1A and age-related macular degeneration: [26], [43], [45] In our cohorts, AMD-associated loci in the complement system genes, LIPC, and ABCA1 also existed (Table S1). VEGF is a key molecule implicated in pathologic retinal angiogenesis variants in VEGFA have been implicated in AMD [46], [47], [48] – although, relationships have not always been replicated. [49], [50], [51], [52] While NV AMD-VEGF relationships did not exist in our cohorts for the SNPs on our microarray feature set (this may have been due to sparse coverage of the gene on the testing panel), we saw value in examining possible interactions with PPARGC1A SNPs.