C3 and age-related macular degeneration: Inferences on the interactions of ω-3 LCPUFA-sensing PPARG-RXR complex constituents with complement and angiogenesis pathway genes in NV AMD are further strengthened by findings from: 1) large-scale population-based studies demonstrating interactions of fish (a primary source of ω-3 LCPUFAs) intake with CFH gene variants in early [53], [54] and late AMD [54]; and 2) ω-3 LCPUFA related alterations in C3 expression and attenuation of pathologic retinal neovascularization in in vivo systems (discussed in the section below).