In bladder cancer, miR-125b also appears to function as a tumor suppressor; miR-125b inhibits E2F3, which is involved in the G1/S phase cell transition, and transfection of miR-125b in bladder cancer cell lines decreased E2F3 protein and cyclin A2, depressing colony formation in vitro and tumor development in mice (Huang et al., 2011). This evidence concerns the gene CCNA2 and urinary bladder carcinoma.