BCL2 and Alzheimer disease: In addition to its activity in the amyloid pathway in AD, down-regulation of miR-29 may allow BH3-only family proteins to inhibit BCL-2 family proteins, leading to apoptosis, while in cancer action of BH3-only family proteins must be blocked somehow, allowing BCL-2 family proteins to promote survival since miR-29 is also down-regulated.