Contrary to these results, a study in glioma found that miR-125b promotes glioma cell proliferation and inhibits drug-induced apoptosis, indicating that it may play an oncogenic role in this particular disease; the authors further found that miR-125b may target and down-regulate apoptosis-related protein BCL-2 modifying factor, and apoptotic activator (BMF;Xia et al., 2009). Here, BMF is linked to central nervous system cancer.