In HCC, miR-29 was found to down-regulate matrix metalloproteinase-2 (MMP2) expression, leading to anti-angiogenesis via subsequent suppression of kinase insert domain receptor (KDR, also called VEGFR2) signaling, as well as anti-invasion effects (Fang et al., 2011). The gene discussed is KDR; the disease is hepatocellular carcinoma.