ARNT and colonic neoplasm: miR-107 has been implicated in angiogenesis in colon cancer; the tumor suppressive transcription factor P53 can mediate transcription of miR-107, and forced expression of miR-107 suppresses expression of hypoxia inducible factor-1beta (HIF-1b), suppressing angiogenesis, tumor growth, and vascular endothelial growth factor (VEGF) expression (Yamakuchi et al., 2010).