CCNA2 and neoplasm: In bladder cancer, miR-125b also appears to function as a tumor suppressor; miR-125b inhibits E2F3, which is involved in the G1/S phase cell transition, and transfection of miR-125b in bladder cancer cell lines decreased E2F3 protein and cyclin A2, depressing colony formation in vitro and tumor development in mice (Huang et al., 2011).