DNMT3A and melanoma: In melanoma, miR-29 expression was inversely correlated with protein levels of DNA methyltransferases DNMT3A and DNMT3B, which affected overall survival (Nguyen et al., 2011); miR-29 expression was also negatively correlated with DNMT3A and B in lung cancer, and transfection of miR-29 restored normal methylation patterns and expression of various tumor suppressor genes, as well as inhibiting tumorigenicity in vitro and in vivo (Fabbri et al., 2007).