From the current literature detailing the tumor suppressive role of miR-195 in various cancers, it is possible to hypothesize that this miRNA has functional overlap with miR-29 and miR-153, both of which have been shown to interact with BCL-2, which would lead to the additional hypothesis that miR-195 is similarly down-regulated in AD. The gene discussed is BCL2; the disease is Alzheimer disease.