Mediation of BCL-2 and MCL-1 by miR-153 indicates that it may have overlapping functionality with miR-29 and 101; however, the majority of evidence indicates that these miRNAs are down-regulated in AD, whereas if they were inhibiting anti-apoptotic molecules, we would expect them to be up-regulated in AD leading to neurodegeneration. The gene discussed is MCL1; the disease is Alzheimer disease.