MCL1 and neoplasm: Down-regulation was associated with many oncogenic characteristics including increased proliferation, invasion, advanced tumor stage, and decreased survival; cellular transfection with miR-101 resulted in increased apoptosis and inhibited proliferation, invasion, and angiogenesis, via inhibition of primary target molecules such as the histone methyltransferase enhancer of zeste homolog 2 (EZH2), COX-2, and MCL-1.