Transfection of miR-146a in prostate cancer cell lines led to significantly reduced expression of ROCK1 and reduced proliferation, invasion, and metastasis; down-regulation of either miR-146a or b in prostate cancer was also linked to focal basal cell layer disruptions, which have been correlated with invasion (Lin et al., 2008;Man et al., 2011). The gene discussed is ROCK1; the disease is Familial prostate cancer.