This miRNA has not been studied as extensively as others mentioned in this review, but is discussed because it has been very recently implicated in regulation of APP.Long et al. (2012) found that delivery of miR-153 in human fetal brain cultures reduced expression of APP, as well as an APP paralog, APLP2, via direct interaction with a target site on the APP 3′ UTR, while inhibition of miR-153 resulted in increased expression of APP; supporting this, decreased miR-153 and increased APP were observed in a subset of AD patients with moderate pathology (Long et al., 2012). This evidence concerns the gene APP and Alzheimer disease.