Analysis in the validation cohort was done by a case-control design and each case was matched to two controls from the same protocol based on sex, age, ALL lineage and ALL risk classification, confirming a significant effect of PACSIN2 SNP rs2413739 on the incidence of severe mucositis during the consolidation therapy of pediatric ALL (Stocco et al., 2012). This evidence concerns the gene PACSIN2 and acute lymphoblastic leukemia.