IFNA1 and systemic lupus erythematosus: Moreover, in contrast to other studies in which the pre-existence of IFN-α is required to prime neutrophils to generate NETs (Garcia-Romo et al., 2011; Lande et al., 2011), this study suggests that IFN-α may have no role in inducing NETs by LDGs, providing a model in which LDGs may precede IFN-α production in SLE.