PKCι also phosphorylates and activates CAK in response to PI-3K signaling in glioma and neuroblastoma cells (Acevedo-Duncan et al., 2002; Pillai et al., 2011; Desai et al., 2012) and may target cyclin E in ovarian cancer (Eder et al., 2005). This evidence concerns the gene PRKCA and glioma.