VEGFA and neoplasm: Tumor cells enter lymphatic vasculature by invading pre-existing lymphatic vessels or by eliciting neo-lymphangiogenesis on the periphery of the tumor, stimulating the secretion of growth factor (VEGF) on tumor-associated fibroblasts and macrophages (Jeltsch et al., 1997; Karpanen et al., 2001; Mandriota et al., 2001; Skobe et al., 2001; Stacker et al., 2001; Schoppmann et al., 2002).