A clear illustration of the antagonistic relationship between 53BP1 and BRCA1 is seen in mouse models, where the embryonic lethality, tumor predisposition, and HR defect of Brca1-deficient mice can be rescued by deleting 53BP1 (Bouwman et al., 2010; Bunting et al., 2010; Cao et al., 2009). This evidence concerns the gene TP53BP1 and neoplasm.