CD8A and hepatocellular carcinoma: Indeed, we found that the MHC-II expressing HCC hepatocytes were positively correlated with the activated CD8+ T cells (CD8 + MHC-II+) after 24 h and 48 h in HCC co-culture (r = 0.947, p < 0.001 and r = 0.878, p = 0.021, respectively).