The ability of this gene to produce a fusion transcript with EWS has been demonstrated in clear-cell sarcoma, defined in the past as malignant melanoma of soft parts (MMSP) [57, 58] More recently, EWS/ATF-1 has been described in soft tissue and angiomatoid fibrous histiocytoma [59–61], and in Hyalinizing clear-cell carcinoma (HCCC), a low-grade salivary gland tumor [62]. The gene discussed is EWSR1; the disease is melanoma.