To investigate whether altering the expression of TPX2 or HMMR/RHAMM is sufficient to modify MPNST cellular responses to AKI, we established stable S462 and 2884 sub-lines that express shRNA targeting TPX2 or HMMR/RHAMM, respectively, as well as a non-hairpin (NHP) shRNA control. This evidence concerns the gene HMMR and acute kidney injury.