The expression level of CRABPII in the primary lesions was relevant to the gender of NSCLC patients, the metastasis and TNM staging of NSCLC (P < 0.05), while the expression level of E-FABP was related to the grading and metastasis of NSCLC (P < 0.05). The gene discussed is CRABP2; the disease is non-small cell lung carcinoma.