The production of both IL-10 and sHLA-G in peripheral blood mononuclear cells (PBMCs) collected from subjects with asthma and stimulated with lipopolysaccharide (LPS) is lower than that seen in similarly-treated cells collected from normal subjects[35], and addition of exogenous IL-10 to asthmatic PBMCs restored sHLA-G production to concentrations seen in normal PBMCs after LPS stimulation[36]. The gene discussed is HLA-G; the disease is asthma.