Therefore, besides the cytokines (TNF-α and IFN-γ) and malaria antigen mediated activation-induced sequestration of the lymphocyte in the lymph nodes, which then causes depletion of these cells in the peripheral blood, malaria antigen-induced apoptosis could also play a role in altering the lymphocyte composition in the peripheral blood during malaria infections [35]. The gene discussed is TNF; the disease is malaria.