It has also recommended that the diagnosis of AD relies on a dual clinicobiological process that entails the evidence of both specific cognitive impairments and biomarkers of AD pathology that can include retention of amyloid tracers on positron emission tomography (PET); cerebral spinal fluid (CSF) beta-amyloid, total tau, and phospho-tau; medial temporal lobe atrophy (MTA) on magnetic resonance imaging (MRI); and/or temporal/parietal hypometabolism on fluorodeoxyglucose (FDG-) PET [12]. The gene discussed is MAPT; the disease is Alzheimer disease.