Also, in highly metastatic cancer cell lines, alpha-dystroglycan frequently lacked laminin binding by silencing of the like-acetylglucosaminyltransferase (LARGE) gene [297], and exogenous expression of LARGE in these cells restored the normal glycosylation and laminin binding of alpha-dystroglycan, leading to reduced cell migration in vitro. The gene discussed is DAG1; the disease is cancer.