Indeed, a fusion protein composed of mouse TNF and a high affinity antibody fragment to the extradomain B (ED-B) domain of fibronectin, a marker of angiogenesis, induced significant antitumour activity against subcutaneously grown F9 embryonal teratocarcinoma, an effect attributed by the authors to targeting of the tumour vasculature [40]). The gene discussed is TNF; the disease is neoplasm.