Since TNF is central in chronic inflammation (important in tumour initiation and progression), drives epithelial to mesenchymal plasticity (facilitating metastasis), is involved in the progression of prostate tumours from an androgen-sensitive to CRPC, and may contribute to the aberrant regulation of eicosanoid pathways (stimulate proliferation and reduce apoptosis), then blockade of TNF could keep PCa progression in check. The gene discussed is TNF; the disease is posterior cortical atrophy.