SB431542 treatment blocked TPA-induced Smad2 phosphorylation in keratinocytes and dermal cells, and TPA-induced skin inflammation, suggesting that the induction of TGFβ1 by TPA [66] and subsequent activation of signaling in keratinocytes and stromal cells is critical for tumor outgrowth, possibly through effects of TGFβ1 on inflammatory gene expression [49]. Here, TGFB1 is linked to neoplasm.