Surprisingly while TPA-induced inflammation was exaggerated in Tgfb1+/− skin, tumors formed in Tgfb1+/+ mice had increased tumor inflammation, and this was paralleled by elevated proinflammatory cytokine expression in v-RasHa-transduced Tgfb1+/+ keratinocytes compared to Tgfb1+/− keratinocytes [47]. Here, TGFB1 is linked to neoplasm.