TAF7L and obesity due to melanocortin 4 receptor deficiency: By using a combination of cellular, biochemical, genetic, and genomic approaches, our findings suggest that TAF7L plays an integral role in adipocyte gene expression by targeting enhancers as a cofactor for PPARγ and promoters as a component of the core transcriptional machinery, therefore providing new molecular insights into fat development that may prove useful for developing therapeutic strategies to treat obesity and its associated diseases.