PPARA and type 2 diabetes mellitus: Furthermore, by coupling T2D GWAS and eSNPs with biological pathways, candidate causal genes, co-expression networks, and BNs, multiple subnetworks and biological processes such as lipid and fatty acid metabolism, calcium signaling, PPAR signaling, TGF-beta signaling, tight junction, complement and coagulation, antigen processing and presentation, and fat cell differentiation were found to be enriched for T2D genetic risks [45•, 46•, 93].