PARK7 and neuroblastoma: When we compare our localization results of E18 mutants with those of Blackinton et al. [45], there is a slight difference: E18D DJ-1, like C106A DJ-1, is localized mainly in the cytoplasm in M17 neuroblastoma cells [45], but E18D DJ-1 was found to be localized in the cytoplasm and mitochondria in DJ-1(−/−) cells in this study (Fig. 2E).