Similarly, Thyroid hormone has been shown to induce HIF-1α expression through THRB/Retinoid X receptor α (RXRα)-dependent activation of the Hepatic leukemia factor (HLF) in human hepatocytes and Hep2 cells [47], a possible role in breast cancer metabolism according to the results of our upstream regulator analysis with IPA software. Here, HLF is linked to breast cancer.