Table 4 shows analogous comparisons as shown Table 3, with late AMD effect estimates replaced with published effect estimates. This analysis produced largely consistent results as the internal comparison. However, in addition to SNPs in CFH, ARMS2/HTRA1 and C2/CFB numerous additional SNPs showed significant effect size differences between early and late AMD – including SNPs in REST, TNFRSF10A, C3, TIMP3 and upstream of LIPC. This evidence concerns the gene REST and age-related macular degeneration.