To further substantiate the functionality of the Dsg2 mAb, we performed dispase-based dissociation assays in a colon carcinoma cell line (Caco-2), in which Dsg2 is the only desmosomal cadherin expressed beside Dsc2 [7], [26] (Fig. 2 E and F). This evidence concerns the gene DSC2 and colon carcinoma.