SOX2 and neoplasm: To test whether FGF5 expression increases in castration-resistant tumor xenografts, we analyzed the castration-resistant LAPC-4 and CWR-R1 tumors described previously (Figure 6C); these data demonstrate that in addition to an increase in Sox2 expression there is a significant increase in FGF5 expression within castration-resistant tumor xenografts (Figure 9B).