These data show that PrEC and CWR lines express detectable levels of Sox2 (R-1: 1.68-fold higher than PrEC; 22Rv1: 0.026-fold that of PrEC) which are substantially below that of pluripotent NCCIT cells and hESCs (Table 1), and the PC-3, Du145, LNCaP, LAPC-4, and VCaP prostate cancer cell lines do not express detectable quantities of Sox2 mRNA. This evidence concerns the gene SOX2 and Familial prostate cancer.