To further determine whether DRibbles-induced antibodies were specific to the antigens expressed by tumor cells, Hep1-6 or control cell line B16F10 cells were incubated with serum collected from Hep1-6/DRibbles-injected mice respectively, and then were stained with FITC-labeled anti-mouse IgM or IgG antibodies. The gene discussed is CD40LG; the disease is neoplasm.