Related to that, we have previously studied, in a cohort of pediatric and adult patients, the presence of a pro-fibrogenic cytokine (TGF-ß1) as well as different matrix deposition markers [hyaluronic acid (HA), type III procollagen amino-terminal peptide (PIIINP) and tissue inhibitor of matrix metalloprotein inhibitor-1 (TIMP-1)] related to liver injury during CHC. Here, TIMP1 is linked to cryohydrocytosis.