Taking into account our previous results on fibrogenesis process direct markers (15) (Table S1), we propose the addition of apoptosis markers, particularly sFas combined with TIMP-1 in pediatric patients and sFas with TGF-ß1, HA, PIIINP in adult patients to more accurately assess liver fibrosis severity. The gene discussed is TIMP1; the disease is Hepatic fibrosis.