Intraepithelial T lymphocytes, particularly CD8+ cells, are the major contributors of IFN-γ and IL-10 in biopsies collected from CD patients with active disease at diagnosis while the relative contribution from T cells in the LP increases in active CD caused by challenge with gluten after a symptom-free period on gluten-free diet [4], [9]. This evidence concerns the gene CD8A and Cowden disease.