HMGCR and neuroblastoma: Moreover, due to the fact that we have previously shown that differentiated NT2-N neurons are a suitable model to study human neuronal cholesterol metabolism, and to corroborate the results obtained in the neuroblastoma cell line, we have used these cells to assess if TSA could also affect the expression levels of HMGCR, the cholesterol synthesis rate-limiting enzyme, in human NT2-N post-mitotic neurons.