CDK4 and systolic heart failure: Some significant pathways in the present study identified through published biomedical databases were related to carcinogenesis (e.g. thyroid carcinoma, down-regulation of breast cancer, etc), specific targets of molecule complex (e.g. NCAM1 interactions, targets of CCND1 and CDK4, CHREBP, and SEMA3B etc.), and regulation of cellular processes or human diseases (e.g. arrhythmogenic right ventricular cardiomyopat, hypertrophic cardiomyopathyhcm and systolic heart failure, hematopoietic stem cell, etc).