There was a significant difference between breast cancer subjects and controls in the distribution of FASL Ivs2nt 124 A/G (rs5030772) genotypes (χ2 = 9.15, p = 0.010) and the GG genotype exhibited significant association with the risk of breast cancer (OR = 5.08; 95% CI = 1.04–18.022; p = 0.012). The gene discussed is FASLG; the disease is breast cancer.