In the present study, we investigate whether the FAS-1377 G/A, FAS-670 A/G, FASL-844 T/C and FASL Ivs2nt 124 A/G polymorphism in cell death pathway genes were associated with the risk of the development of breast cancer in a sample of Iranian population (south east of Iran). The gene discussed is FAS; the disease is breast carcinoma.